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Rev. Fac. Cienc. Méd. (Quito) ; 43(2): 161-166, dic. 2018.
Article in Spanish | LILACS | ID: biblio-1361787

ABSTRACT

Contexto: la leishmaniosis es una enfermedad parasitaria causada por veinte especies diferentes del protozoario Leishmania y transmitida al hombre por la picadura del mosquito hembra del género Phlebotomine. Las manifestaciones clínicas son variables y se relacionan con la especie infestante, su relación con el medio ambiente y respuesta inmune del hospedero. La leishmaniosis cutánea (LC) y mucocutánea (LMC) afecta a piel y mucosas de vías respiratorias superiores; está presente en Latinoamérica donde es producida principalmente por la especie Leishmania (Viannia) braziliensis. Los signos iniciales son eritema y ulceraciones a nivel de orificios nasales seguido por inflamación destructiva que puede extenderse hasta afectar el septo nasal y en algunos casos faringe o laringe, desfigurando gravemente el rostro y comprometer la vida del paciente. Presentación de caso: se presenta el caso de un hombre de 90 años de edad, procedente del noroccidente de la Provincia de Pichincha; exhibe varias lesiones ulcerativas localizadas a nivel del puente nasal derecho, ángulo interno del ojo derecho y mejilla homolateral, cubriendo un área aproximada de 4 cm de diámetro. Inicialmente se sospechó de LMC y se aplicaron varias dosis de antimonio pentavalente (Glucantime©). Se realizaron exámenes diagnósticos para leishmaniosis (frotis, cultivo y prueba cutánea de Montenegro) los cuales resultaron negativos. El estudio histopatológico determinó que se trataba de un carcinoma basocelular de piel (CBC). Conclusiones: en zonas endémicas de LC y LMC, es necesario realizar un adecuado diagnóstico diferencial con otras patologías que causan lesiones ulcerativas, entre las que se incluye el carcinoma basocelular de piel, evitando administrar antimonio pentavalente de manera indiscriminada.


Context: Leishmaniasis is a parasitic disease caused by twenty different species of the Leishmania protozoan and transmitted to man by the bite of the female mosquito of the genus Phle- botomine. The clinical manifestations are variable and are related to the infestant species, its relationship with the environment and the host's immune response. Cutaneous and mucocutaneous (LMC) leishmaniasis affects the skin and mucous membranes of the upper respiratory tract; It is present in Latin America where it is mainly produced by the species Leishmania (Viannia) braziliensis. The initial signs are erythema and ulcerations at the level of nostrils followed by destructive inflammation that can extend to affect the nasal septum and in some cases pharynx or larynx, seriously disfiguring the face and compromising the patient's life. Case presentation: The case of a 90-year-old man from the northwest of the Pichincha Province is presented; It presents several ulcerative lesions located at the level of the right nasal bridge, internal angle of the right eye and homolateral cheek, covering an area approximately 4 cm in diameter. Initially, CML was suspected and several doses of pentavalent antimony (Glucantime©) were applied. Diagnostic tests were performed for leishmaniasis (smear, culture and skin test of Montenegro) which were negative. The histopathological study determined that it was a basal cell carcinoma of the skin (CBC). Conclusions: In endemic areas of LC and CML, it is necessary to make an adequate differential diagnosis with other pathologies that cause ulcerative lesions, including basal cell carcinoma of the skin, avoiding administering pentavalent antimony indiscriminately.


Subject(s)
Humans , Male , Aged, 80 and over , Skin Ulcer , Carcinoma, Basal Cell , Leishmaniasis, Cutaneous , Diagnosis, Differential , Dermoscopy , Leishmania
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